Currently, data on safety and efficacy of a new health-care intervention should be complemented with effectiveness data to demonstrate the effects of these interventions in real world conditions. To enable this, PORIB focuses on:

• The design, coordination, monitoring and interpretation of studies of effectiveness:
  - Observational studies
  - Pragmatic clinical trials
  - Retrospective studies through review of databases
• The development, validation and interpretation of measures and scales of patients' reported outcomes:
  - Health-related quality of life
  - Treatment satisfaction, preferences and expectations
  - Disability level
• Design and development of epidemiological studies
• The statistical analyses for clinical and epidemiological research, social and health services, and presentation and interpretation of results
• The conduct and adaptation of Clinical Practice Guidelines based on scientific evidence, systematic reviews and consensus statements